Studies, frequently asked questions and answers

Collagen is one of the most important types of protein found in our bodies. It is made up of 19 different amino acids and makes up 30% of all protein in the human body. It is found in connective tissue, cartilage, bone, tendons and skin.

From around the age of 20, collagen production starts to decline and from the age of 30, the decline is faster and the ageing process becomes more pronounced – wrinkles deepen, skin loses elasticity, pigment spots may appear, nails become brittle, cellulite worsens, hair falls out more often and is of poorer quality. Movement is also more strenuous, causing pain in the joints and cartilage. If we want to prolong our youthful appearance and active movement without pain, we need to incorporate quality collagen supplements into our lives.

Startes® collagen peptides can help you meet your exact needs. We offer collagens with unique properties. They are formulated for maximum results in the following areas:
* Beauty and youthfulness: Firm and hydrate skin, reduce wrinkles and stretch marks, promote hair and nail growth.
* Joint and cartilage health: relieve joint pain and inflammation, improve mobility and flexibility, regenerate cartilage tissue.
* Ligaments and tendons health: strengthen and strengthen ligaments and tendons, prevent injuries, speed recovery.

VERISOL®, FORTIGEL® and TENDOFORTE® are collagen-type peptides that have specific health effects. Their very small molecular size allows them to enter our cells. VERISOL® peptides stimulate collagen cells in our skin and FORTIGEL® peptides stimulate collagen cells in our cartilage and joints. TENDOFORTE® peptides stimulate tendoncytes (tendon cells) and ligamentocytes (ligament cells). Peptides are incomparably more effective than commercial collagen and the results are backed up by studies.

"Startes® collagen peptides have positive effects on the body and are backed up by independent studies. I recommend it to my patients and use it myself for joints and cartilage.

Doc. MUDr. Zdenek Volny - Startes® Hydrolyzovaný Kolagen - Krása a mladistvý vzhled 153G
Doc. MUDr. Zdeněk Volný
Dermatovenerologist and General Practitioner
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Do you also come across collagen products which, according to the label, work on the whole of the body? Neutral” collagen does it all, from smoothing out wrinkles to enabling pain-free movement. That would be the case in an ideal world.

Bioactive collagen peptides are specifically optimized for so-called physiological benefits. The peptides are derived from a highly controlled collagen production process determined by the conditions of hydrolysis. As a result, bioactive collagen peptides differ in their physiological functionality. They are optimised to maximise the stimulation of the human cell types involved in collagen biosynthesis.

In layman’s terms, there is raw native collagen, from which a patented manufacturing process produces specific bioactive collagen peptides which, because of their physiological function (e.g. molecular weight), “affect and attract” the cells in the body for which they are “made”. For example, collagen for “Beauty and Youthfulness” acts on fibroblast cells we have in our skin. The collagen for “Joints and Cartilage” affects the chondrocyte cells found in joints and the collagen for “Tendons and Ligaments” affects tendoncytes (tendon cells) and ligamentocytes (ligament cells).

Each person’s body responds to collagen supplementation in a different way. In general, first results can be expected within 8 to 12 weeks (VERISOL®) and 12 to 24 weeks (FORTIGEL®, TENDOFORTE®). For the full benefits of collagen, our recommendation is at least 6-9 months of use.

There are many independent studies that prove the benefits of collagen for the body.

With regard to VERISOL®, for example, a 2013 study by the authors of E. Proksch 1, D. Segger, J. Degwert, M. Schunck, V. Zague, S. OesserIn the first group of 69 women aged 35 to 55 years, skin elasticity was increased by up to 15% after 4 weeks of supplementation with VERISOL® (2,500 mg) compared to placebo. In the second group of 100 women aged 45 to 65, wrinkles were significantly reduced and skin collagen levels increased by up to 60%.

A 2015 study by the group of authors M. Schunck, V. Zague, S. Oesser, E. Proksch studied 105 women between the ages of 25 and 50, and the results of ultrasound testing showed a significant improvement in skin layers and a reduction in cellulite after 6 months in women with a BMI below 25.

A 2017 study by a group of authors including D. Hexsel, V. Zague, M. Schunck, C. Siega, FO. Camozzato and S. Oesser examined the effect of VERISOL® on nail quality and growth. After 2 months of use, there was a reduction in nail brittleness, and after 6 months the results showed up to 42% less nail brittleness than the placebo control group. Nail growth was statistically improved after 3 months of supplementation.

In the recent 2020 study by S. Oesser, VERISOL® was shown to improve hair appearance and texture (strength, thickness and shine). The study enrolled 44 healthy women, aged 39 to 75 years, who were each given 2,500 mg of VERISOL® per day or placebo maltodextrin for 16 weeks. Cell culture monitoring showed a significant 31% increase in human hair follicle cell proliferation, indicating a positive effect on hair metabolism.

With regard to FORTIGEL®, a study was carried out in 2008 by the University of Pennsylvania (USA) in which 147 professional athletes with an average age of 20 years took FORTIGEL® or a placebo for 24 weeks. Improved joint mobility and reduced pain were seen in athletes taking FORTIGEL®.

A study published in 2011 by McAlindon and colleagues examined the long-term effect of FORTIGEL® treatment on hyaline cartilage composition in subjects with early knee osteoarthritis. A total of 30 subjects in one group were randomised to receive a daily dose of 10,000 mg of FORTIGEL® for a period of 48 weeks. The control group only received a placebo. Three MRI scans of the knee were performed on each subject, one at baseline, one at 24 weeks, and a final scan at 48 weeks. Analysis of the cartilage scans showed a statistically significant increase in proteoglycan density in the medial and lateral tibial regions in subjects treated with FORTIGEL® compared to the placebo group. The results show that oral supplementation with FORTIGEL® has a direct effect on human cartilage tissue.

In a randomised, double-blind, placebo-controlled study conducted by Zdzieblik in 2021, physically active young adults with knee pain (at least 3 hours of exercise per week) received daily supplementation with 5 g of FORTIGEL® collagen peptides or placebo for 12 weeks. The study was completed by 180 active men and women aged 18 to 30 years with exercise-induced knee pain but no diagnosed joint disease. The participants were randomly assigned to a group that received 5 g of FORTIGEL® collagen peptides or to a group that received a placebo. Study results show a statistically significant reduction in “pain during activity” after oral administration of FORTIGEL® collagen peptides compared to placebo. This is how it was rated by the study participants and the doctor. At the same time, FORTIGEL® collagen peptides have been shown to reduce knee pain during activity and may help prevent the clinical manifestations of chronic degenerative joint disease.

In an in vitro experiment, fibroblasts derived from human ligaments and Achilles tendons were able to produce significantly more tissue matrix (1.2 to 2.4 times) when directly exposed to the bioactive collagen peptides contained in TENDOFORTE®. Collagen RNA expression increased significantly and elastin synthesis – the major component of the connective tissue matrix – increased by approximately 50%; tissue degradation was also reduced. This was the first study to suggest a role for bioactive collagen peptides in reducing the risk of injury and rupture of ligaments and tendons.

A 2017 study by the Australian Institute of Sport (AIS) examined the benefits of supplementing with TENDOFORTE® for 6 months (cross-over design). It involved 20 people with long-term symptoms of chronic Achilles tendinopathy who had not responded to conventional therapy and were unable to train. Within 3 months, 12 out of 20 participants were able to return to running after starting therapy with a daily intake of 5g of TENDOFORTE® combined with a highly specialised exercise programme. Moreover, the effect is long-lasting. In the group that started taking TENDOFORTE® in the crossed design, the beneficial effects were still evident 3 months after stopping.

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Although collagen is the most abundant and important type of protein in our bodies, we recommend that you consult your doctor about supplementation during pregnancy. However, it is recommended after childbirth or while breastfeeding – it can help with stressed joints, thicker hair, stronger nails, stretch marks and cellulite.

Our collagen is of animal origin – pork. Pork is structurally and genetically closest to human skin/tissue. It is also used in transplant medicine (e.g. heart valve replacement).

The pack Startes® Hydrolysed Collagen – Beauty and Youthfulness lasts for up to 60 days. The dose may be doubled for the first 30 to 60 days. After that, the normal dose can be continued.
The pack Startes® Hydrolysed Collagen – Joints and Cartilage lasts for 20 days. As 1 daily dose contains up to 10,000 mg of FORTIGEL®, the dose can be halved (5,000 mg) for people under 35 years of age, and the pack will then last for 40 days. In general, we recommend the standard dose for severe joint damage or pain with movement. For the maintenance phase and for prevention, the dose can be reduced by half.
The pack Startes® Hydrolysed Collagen – Tendons and Ligaments lasts for 25 days.

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We want to offer our customers a natural form of collagen. There are no added sweeteners, preservatives or chemical flavours. This means you can use collagen safely for a long time. You can mix it into any drink, yoghurt or porridge you like.

When collagen is added to water or other liquids, lumps may sometimes form. Allow the collagen to stand in the liquid for a few minutes, then stir again to dissolve the powder completely.

Vitamin C is important for an even better stimulation of the collagen in the body. Research has shown that it stabilises collagen mRNA. This increases collagen protein synthesis to repair damaged skin.